Bullets fired through suppressors are generally subsonic to avoid the 'crack' of the bullet breaking the sound barrier, so they'll be a bit slower coming out of the barrel, maybe get more bullet drop over long ranges due to slower speed, probably not a big issue for the shortish ranges these types of long are used at though.
That's a different can of worms. Suppressed/silenced pistol calibre weapons (DeLisle, Welrod, Mk5 Sterling, Sten MkII(S) & Mk VI) usually use sub-sonic ammunition to avoid the crack. The Sterling & Sten had drilled barrels to vent some of the gas and so make standard 9mm ammo sub-sonic. The pistol's MV is usually close to, or less than, the speed of sound anyway, it doesn't make a lot of difference.
The rear sight for the Mk5 Sterling looked similar (other than the bunch of holes around the rearsight aperture) but was different to the standard Mk4 SMG sight because of the differences in muzzle velocity.
You just can't avoid the crack with rifle ammunition, you can only reduce the noise caused by gas being released from the weapon on firing. It makes the firer harder to find and reduces hearing damage.