Boot up puter and before the Win logo comes up press f8 on keyboard it`s a bit tricky if you miss it boot again.
You should see a menu
Go to "start in save mode with network support"
It only loads the critical system data and then try to run you progs to remove it or if you know what file is infected you can remove it.
Saw this post by accident whilst looking for something else - I've had a problem for about the last week which I had been unable to resolve - decided to give Super Anti Spyware a go, it sorted it in about 10 minutes! Magic. Thanks for the tip.
worst case isolate your documents (put it on a memory stick or hard drive) if you have a recovery disk, recommend you format it. then get yourself protected again, and then check the memory stick or hard drive) for any viruses or problems
this is an extreme and worst case option.. however for future thought if possible try and use an external harddrive where possible and not your local..
This may just be the push I've needed to bite the bullet and get a larger hard drive. I've been running 2 80gb, its about time I got a decent large drive. I've knocked my computer off for the night and i'm posting this on my phone. Thanks for all the replies so far, i'm quite lucky in that I backed a lot of my data to disc when I first installed vista so I haven't got that much to back up. I'll try and get it sorted, but failing that, I might wait and get MS7 as well as a new hard drive and put both in at the same time.