short-fuse seems to have it sussed!
see if you can stay near the "Old Town Square (Staromìstské námìstí)" big main square with huge statue of Jan Hus (their Martin Luther - actually he lived 300 years before ML, but this is not a history lesson).
top spots:
Jewish Quarter - with the cementary - this can freak you out. Musuem there established by the Nazis, which was suppose to demonstrate how nasty the Jews were - needless to say it is a chilling memorial to the Holacost.
Excellent walk - from old town square, head toward Charles Bridge (one with the statues), across, head up the street and towards the castle (big thing on the hill - can't miss it). Its a long walk up, but well worth it. Then whilst up there head to the catherdal. Stunning views over the city and countryside
Best part - every 50 yards will be another pub!
YOU MUST DRINK BECKEROVKA - its the local liquer

with woman it acts like an aphrodisiac
anyway, i could go on for hours - best tourist site -
www.prague.cz - they do an english version
go on - you'll love it